排序方式: 共有55条查询结果,搜索用时 31 毫秒
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Hiroko Yokokawa 《Phytochemistry》1980,19(12):2615-2618
The simple lipids present in ten species of Polyporaceae (Piptororus betulinus, Coriolus pargamenus, C. versicolor, C. heteromorphus, Formitopsis cytisina, F. pinicola, Microporus flabelliformis, Gloephyllum saepiarium, Crytoderma citrinum and Grifola frondosa) were investigated. The fatty acids that these species had in common were C16-saturated acids (except in P. betulinus) and C18-unsaturated acids. Ergosterol and ergosta-7,22-dien-3β-ol were isolated from these mushrooms. Lupeol was obtained from G. saepiarium. Ergost-7-en-3β-ol, lanosterol and 24-methylene-24,25-dihydrolanosterol were tentatively identified. 相似文献
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Minkyun Na Bo Yeon Kim Hiroyuki Osada 《Journal of enzyme inhibition and medicinal chemistry》2013,28(4):1056-1059
Protein tyrosine phosphatase 1B (PTP1B) appears to be an attractive target for the development of new drugs for type 2 diabetes and obesity. In our preliminary test, a MeOH extract of the stem barks of Sorbus commixta Hedl. (Rosaceae) showed strong PTP1B inhibitory activity. Bioassay?guided fractionation of the MeOH extract resulted in the isolation of two lupane?type triterpenes, lupenone (1) and lupeol (2). Compounds 1 and 2 inhibited PTP1B with IC50 values of 13.7 ± 2.1 and 5.6 ± 0.9 μM, respectively. Kinetic studies revealed that both the compounds 1 and 2 are non?competitive inhibitors of PTP1B that decrease Vmax values with no effect on Km values. 相似文献
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羽扇豆醇是一种植物天然提取物,具有高效低毒的抗癌活性,对于药物开发领域有很高价值。目前对其抗癌机制还不是十分明确。使用TaqMan MicroRNA Assay芯片技术,从羽扇豆醇处理的hela细胞中miRNA的差异表达入手,探索扇豆醇抗癌分子途径。运用聚类分析等统计学方法和targetscan,RNAfold等序列分析工具进行信号组分的预测筛选,再结合对NC-BI,Gene Ontology等大型生物信息数据库的检索,最终在生物信息学层面上,分析得到hela细胞中羽扇豆醇抗癌的分子调控途径,即以受体酪氨酸激酶ERBB4介导的,hsa-miR-23b,hsa-miR-200b等几种miRNA参与的分子通路。 相似文献
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Lup-20(29)-ene-3β,11β-diol and lupeol have been isolated from Dodonaea attenuata A. Cunn. var. linearis Benth. 相似文献
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The neutral components from the stems of Colletia spinosissima Gmel. include lupenone, sitosterol lupeol, daucosterine. Acid hydrolysis of the glycoside fraction afforded ethyl sinapate and two homologous degradation products from the corresponding sapogenins. Mild hydrolysis of the glycoside fraction afforded the intact sapogenins, which have been tentatively assigned the structures (VIIb) and (VIIIb). The chemistry of the latter compounds has been explored. 相似文献
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Swapnadip Thakur Prantika Das Toshihiro Itoh Kazunori Imai Taro Matsumoto 《Phytochemistry》1984,23(9):2085-2087
The hexane and methanol soluble extract of the latex coagulum of Calotropis gigantea afforded two new triterpene esters, viz. 3′-methylbutanoates of α-amyrin and ψ-taraxasterol, besides the known 3′-methylbutanoates of three triterpene alcohols. The compositions of the alkane fraction, total triterpene alcohol fraction, and free, acetyl and 3′-methylbutanoyl triterpene alcohol fractions of the extract were determined. 相似文献
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The ethanol extract of Cnidosculus urens yielded β-amyrin cinnamate and germanicol acetate. Also, using 13C NMR spectroscopy, mixtures of β-amyrin, germanicol and lupeol as well as their acetates were identified. 相似文献